Numerical Analysis of Hollow Microneedle and Soft Tissue Interaction

Abstract

Microneedles play a significant role in drug delivery by reducing the insertion pain. In this paper, the safety of the microneedle is analyzed numerically when it is inserted into the transdermal region of the human body during the drug delivery. The microneedle failure is avoided by observing the effect of stress created in the contact between microneedle and soft tissue of human skin. The model of the soft tissue and the microneedle is generated using FEA. Next, both the model are interfaced to study the effect of interfacial contact stress. Also, the deflection of the microneedle is studied. The Factor of Safety is determined to ensure the safe and successful insertion of the microneedle into the soft tissue for drug delivery. The optimal design of microneedle will improve the efficiency of drug delivery into the human body.