Synthesis, Characterisation And Antibacterial Activity Of Some New Schiff Bases.

Abstract

Schiff's bases are  compounds of the aldehyde or ketone type in which the carbonyl group is replaced by an imine  or azomethine group. It contains a carbon-nitrogen double bond with the nitrogen atom  connected to an aryl or alkyl group but no hydrogen. Many metal complexes of Schiff bases  have been studied to treat various bacterial, fungal, viral infections and neurological disorders. Metal complexes have a high place in pharmaceutical chemistry due to  their different reactions to non-metals. Extensions of biological activity from the implementation of transition metals at Schiff bases have been reported. Schiff bases are widely used in analytical, organic and inorganic  chemistry. Among azomethane derivatives, C = N connections are various natural  (antistrocladidine has antimalarial activity), natural-derived (chitosin-derived shift bases have  antifungal action) and non-compatible compounds required for biological activity. Many  azomethanes have important antibacterial, antifungal, anticancer and diuretic activities. In addition to biological activities, finds application in many other fields such as organic synthesis, dyes, pigments, polymer stabilizers, corrosion  inhibitors, fungicides, agrochemicals, analytical chemistry, electrical conductivity, magnetism,  host guest chemistry and catalysis.Due to these important  applications, we have synthesized various new Schiff bases  and other heterocyclic compounds along with their characterisation ( IR, 1HNMR and mass) and antibacterial evaluation on plant and human pathogenic bacterial strains. All the compounds showed excellent antibacterial activity against the pathogenic strains.